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Maternal-Fetal Medicine

Serial Amnioreductions

Serial amnioreduction is a nonsurgical treatment for Twin-to-Twin Transfusion Syndrome (TTTS).

It involves the removal of the excess fluid from around the recipient twin with a needle, similar to an amniocentesis.

The procedure may temporarily restore the balance in the volumes of amniotic fluid of both twins, and is typically repeated multiple times over the course of the pregnancy, as the fluid tends to re-accumulate.

Removing the excess fluid decreases the risk of preterm labor, and reduces possible abdominal discomfort and difficulty breathing for the mother.
This technique is often recommended for milder cases of TTTS or cases occurring after 26 weeks of pregnancy. It is not effective for severe TTTS.

Results for serial amnioreductions are:

  • 40-50% survival rate of at least one twin
  • Approximately 25% of the surviving twin suffers some brain damage

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